B Cell Depletion and SARS-CoV-2 Vaccine Responses in Neuroimmunologic Patients.

ABSTRACT:

Objective

The study was undertaken to assess the impact of B cell depletion on humoral and cellular immune responses to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) vaccination in patients with various neuroimmunologic disorders on anti-CD20 therapy. This included an analysis of the T cell vaccine response to the SARS-CoV-2 Delta variant.

Methods

We investigated prospectively humoral and cellular responses to SARS-CoV-2 mRNA vaccination in 82 patients with neuroimmunologic disorders on anti-CD20 therapy and 82 age- and sex-matched healthy controls. For quantification of antibodies, the Elecsys anti-SARS-CoV-2 viral spike (S) immunoassay against the receptor-binding domain (RBD) was used. IFN-gamma enzyme-linked immunosorbent spot assays were performed to asse

SUBMITTER: Kornek B 

PROVIDER: S-EPMC9011809 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature