Factors predicting serum clozapine levels in Middle Eastern patients: an observational study.

ABSTRACT:

Background

Despite its superiority over other drugs for psychosis, clozapine remains underused and is associated with many clinical challenges, including difficulties in predicting therapeutic serum levels (350-600 ng/mL). We found no large or recent study that investigated the determinants of serum clozapine levels in Middle Eastern patients. Therefore, we investigated the association between clozapine dose and serum level, and the clinical predictors of the clozapine serum level, in Middle Eastern patients.

Methods

This cross-sectional study included 94 patients of Middle Eastern ethnicity who attended the Clozapine Clinic in King Saud University Medical City in Riyadh, Saudi Arabia. We used a single measure of the serum clozapine level, which was collected 12 h after the

SUBMITTER: Hassab Errasoul A 

PROVIDER: S-EPMC9011948 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature