Early and strong antibody responses to SARS-CoV-2 predict disease severity in COVID-19 patients.

ABSTRACT:

Background

Antibody response to SARS-CoV-2 is a valuable biomarker for the assessment of the spread of the virus in a population and evaluation of the vaccine candidates. Recent data suggest that antibody levels also may have a prognostic significance in COVID-19. Most of the serological studies so far rely on testing antibodies against spike (S) or nucleocapsid (N) protein, however antibodies can be directed against other structural and nonstructural proteins of the virus, whereas their frequency, biological and clinical significance is unknown.

Methods

A novel antigen array comprising 30 SARS-CoV-2 antigens or their fragments was developed and used to examine IgG, IgA, IgE and IgM responses to SARS-CoV-2 in sera from 103 patients with COVID-19 including 34 patients for who

SUBMITTER: Plume J 

PROVIDER: S-EPMC9012069 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature