Standardized genome-wide function prediction enables comparative functional genomics: a new application area for Gene Ontologies in plants.

ABSTRACT:

Background

Genome-wide gene function annotations are useful for hypothesis generation and for prioritizing candidate genes potentially responsible for phenotypes of interest. We functionally annotated the genes of 18 crop plant genomes across 14 species using the GOMAP pipeline.

Results

By comparison to existing GO annotation datasets, GOMAP-generated datasets cover more genes, contain more GO terms, and are similar in quality (based on precision and recall metrics using existing gold standards as the basis for comparison). From there, we sought to determine whether the datasets across multiple species could be used together to carry out comparative functional genomics analyses in plants. To test the idea and as a proof of concept, we created dendrograms of functional relate

SUBMITTER: Fattel L 

PROVIDER: S-EPMC9012101 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature