The road to precision psychiatry: translating genetics into disease mechanisms.

ABSTRACT: Hundreds of genetic loci increasing risk for neuropsychiatric disorders have recently been identified. This success, perhaps paradoxically, has posed challenges for therapeutic development, which are amplified by the highly polygenic and pleiotropic nature of these genetic contributions. Success requires understanding the biological impact of single genetic variants and predicting their effects within an individual. Comprehensive functional genomic annotation of risk loci provides a framework for interpretation of neurobiological impact, requiring experimental validation with in vivo or in vitro model systems. Systems-level, integrative pathway analyses are beginning to elucidate the additive, polygenic contributions of risk variants on specific cellular, molecular, developmental, or circu

SUBMITTER: Gandal MJ 

PROVIDER: S-EPMC9012265 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature