Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration.

ABSTRACT: Many of our daily activities, such as riding a bike to work or reading a book in a noisy cafe, and highly skilled activities, such as a professional playing a tennis match or a violin concerto, depend upon the ability of the brain to quickly make moment-to-moment adjustments to our behavior in response to the results of our actions. Particularly, they depend upon the ability of the neocortex to integrate the information provided by the sensory organs (bottom-up information) with internally generated signals such as expectations or attentional signals (top-down information). This integration occurs in pyramidal cells (PCs) and their long apical dendrite, which branches extensively into a dendritic tuft in layer 1 (L1). The outermost layer of the neocortex, L1 is highly conserved across cort

SUBMITTER: Schuman B 

PROVIDER: S-EPMC9012327 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature