Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition.

ABSTRACT: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigmatic. As IECs serve as the primary barrier between underlying host immune cells, we reasoned that IEC-intrinsic antigen presentation may play a role in responses toward the microbiota. Mice with an IEC-intrinsic deletion of MHC class II (IEC^{ΔMHC class II}) are healthy but have fewer microbial-bound IgA, regulatory T cells (Tregs), and immune repertoire selection. This was associated with increased interindividual microbiota variation and altered proportions of two taxa in the ileum where MHC cla

SUBMITTER: Stephens WZ 

PROVIDER: S-EPMC9012449 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature