Prognostic and Functional Analysis of NPY6R in Uveal Melanoma Using Bioinformatics.

ABSTRACT: Neuropeptides can mediate tumor cell proliferation and differentiation through autocrine, paracrine, neurosecretory, and endocrine mechanisms. This study investigated the expression and prognostic significance of neuropeptide Y receptor Y6 (NPY6R) in uveal melanoma (UVM) and preliminarily investigated the biological function of NPY6R in UVM. NPY6R was poorly expressed in most tumors and was associated with better prognosis in UVM. Among the clinicopathological features of UVM, NPY6R expression was lower in male patients. The area under the curve (AUC) value of NPY6R for the diagnosis of UVM was 0.676 (95% CI: 0.556-0.795). A nomogram including four clinical predictors was constructed. NPY6R expression was significantly associated with features of the UVM

SUBMITTER: Mei S 

PROVIDER: S-EPMC9012612 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature