Modelling normal and nephrotic axial uptake of albumin and other filtered proteins along the proximal tubule.

ABSTRACT: Recent studies indicate that filtered albumin is retrieved in the proximal tubule (PT) via three pathways: receptor-mediated endocytosis via cubilin (high affinity) and megalin (low affinity), and fluid-phase uptake. Expression of megalin is required to maintain all three pathways, making it challenging to determine their respective contributions. Moreover, uptake of filtered molecules varies between the sub-segments (S1, S2 and S3) that make up the PT. Here we used new and published data to develop a mathematical model that predicts the rates of albumin uptake in mouse PT sub-segments in normal and nephrotic states, and partially accounts for competition by β₂ -microglobulin (β2m) and immunoglobulin G (IgG). Our simulations indicate that receptor-mediated, rather than fluid-pha

SUBMITTER: Edwards A 

PROVIDER: S-EPMC9012691 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature