Serotonergic system in vivo with [¹¹C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients.

ABSTRACT: GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in the brain of`DRD patients and correlate this to (non-)motor symptoms. Dynamic [¹¹C]DASB PET scans, a marker of serotonin transporter availability, were performed. Ten DRD, 14 cervical dystonia patients and 12 controls were included. Univariate- and network-analysis did not show differences in binding between DRD patients compared to controls. Sleep disturbances were correlated with binding in the dorsal raphe nucleus (all participants: r_s = 0.45, p = 0.04; patients: r_s =

SUBMITTER: Timmers ER 

PROVIDER: S-EPMC9012759 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature