Culture and multiomic analysis of lung cancer patient-derived pleural effusions revealed distinct druggable molecular types.

ABSTRACT: Malignant pleural effusion (MPE) is an independent determinant of poor prognostic factor of non-small cell lung cancer (NSCLC). The course of anchorage independent growth within the pleural cavity likely reforms the innate molecular characteristics of malignant cells, which largely accounts for resistance to chemotherapy and poor prognosis after the surgical resection. Nevertheless, the genetic and transcriptomic features with respect to various drug responses of MPE-complicated NSCLC remain poorly understood. To obtain a clearer overview of the MPE-complicated NSCLC, we established 28 MPE-derived lung cancer cell lines which were subjected to genomic, transcriptomic and pharmacological analysis. Our results demonstrated MPE-derived NSCLC cell lines recapitulated representative driver muta

SUBMITTER: Seo HY 

PROVIDER: S-EPMC9012760 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature