Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain.

ABSTRACT: Neuroimaging studies have suggested a link between the intensity of chronic low back pain intensity and structural and functional brain alterations. However, chronic pain results from the coordination and dynamics among several brain networks that comprise the dynamic pain connectome. Here, we use resting-state functional magnetic resonance imaging and measures of static (sFC) and dynamic functional connectivity (dFC) variability in the typical (0.01-0.1 Hz) and five specific (slow-6 to slow-2) frequency bands to test hypotheses regarding disruption in this variability in low back-related leg pain (LBLP) patients who experience chronic pain and numbness. Twenty-four LBLP patients and 23 healthy controls completed clinical assessments, and partial correlational analyses between altered sFC

SUBMITTER: Pei Y 

PROVIDER: S-EPMC9012841 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature