Reticulon 2 promotes gastric cancer metastasis via activating endoplasmic reticulum Ca²⁺ efflux-mediated ERK signalling.

ABSTRACT: Gastric cancer ranks fourth for mortality globally among various malignant tumours, and invasion and metastasis are the major reason leading to its poor prognosis. Recently, accumulating studies revealed the role of reticulon proteins in cell growth and transmigration. However, the expression and biological function of reticulon proteins in human gastric cancer remain largely unclear. Herein, we explored the potential role of reticulon 2 (RTN2) in the progression of gastric cancer. Tissue microarray was used to determine the expression levels of RTN2 in 267 gastric cancer patients by immunohistochemistry. Gastric cancer cell lines were utilised to examine the influences of RTN2 on cellular migration and invasion abilities, epithelial-to-mesenchymal transition (EMT) and signalling pathway.

SUBMITTER: Song S 

PROVIDER: S-EPMC9012842 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature