Feasibility of circulating tumor DNA analysis in dogs with naturally occurring malignant and benign splenic lesions.

ABSTRACT: Comparative studies of naturally occurring canine cancers have provided new insight into many areas of cancer research. Development and validation of circulating tumor DNA (ctDNA) analysis in pet dogs can help address diagnostic needs in veterinary as well as human oncology. Dogs have high incidence of naturally occurring spontaneous cancers, demonstrate molecular heterogeneity and clonal evolution during therapy, allow serial sampling of blood from the same individuals during the course of disease progression, and have relatively compressed intervals for disease progression amenable to longitudinal studies. Here, we present a feasibility study of ctDNA analysis performed in 48 dogs including healthy dogs and dogs with either benign splenic lesions or malignant splenic tumors (hemangiosarc

SUBMITTER: Favaro PF 

PROVIDER: S-EPMC9012871 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature