Quantitative imaging parameters to predict the local staging of prostate cancer in intermediate- to high-risk patients.

ABSTRACT:

Objectives

PSMA PET/MRI showed the potential to increase the sensitivity for extraprostatic disease (EPD) assessment over mpMRI; however, the interreader variability for EPD is still high. Therefore, we aimed to assess whether quantitative PSMA and mpMRI imaging parameters could yield a more robust EPD prediction.

Methods

We retrospectively evaluated PCa patients who underwent staging mpMRI and [⁶⁸Ga]PSMA-PET, followed by radical prostatectomy at our institution between 01.02.2016 and 31.07.2019. Fifty-eight cases with PET/MRI and 15 cases with PET/CT were identified. EPD was determined on histopathology and correlated with quantitative PSMA and mpMRI parameters assessed by two readers: ADC (mm²/1000 s), longest capsular contact (LCC, mm), tumor volume

SUBMITTER: Laudicella R 

PROVIDER: S-EPMC9012878 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature