Genetic and Epidemiologic Analyses of an Outbreak of Pneumocystis jirovecii Pneumonia Among Kidney Transplant Recipients in the United States.

ABSTRACT:

Background

Pneumocystis jirovecii is an opportunistic fungus that causes Pneumocystis pneumonia (PCP) in immunocompromised hosts. Over an 11-month period, we observed a rise in cases of PCP among kidney-transplant recipients (KTR), prompting an outbreak investigation.

Methods

Clinical and epidemiologic data were collected for KTR diagnosed with PCP between July 2019 and May 2020. Pneumocystis strain typing was performed using restriction fragment length polymorphism analyses and multilocus sequence typing in combination with next-generation sequencing. A transmission map was drawn, and a case-control analysis was performed to determine risk factors associated with PCP.

Results

Nineteen cases of PCP in KTR were diagnosed at a median of 79 months post-transplantation; 8

SUBMITTER: Azar MM 

PROVIDER: S-EPMC9012955 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature