Stability of Varenicline Concentration in Saliva Over 21 Days at Three Storage Temperatures.

ABSTRACT:

Introduction

Varenicline is the most efficacious drug for smoking cessation; saliva varenicline concentrations can be useful for the evaluation of adherence in smoking cessation trials. Saliva is a useful noninvasive matrix for mail-in specimen collection, if stable. We investigated the stability of varenicline in saliva at different storage temperatures simulating the time it takes to mail in a sample.

Methods

We evaluated the concentrations of varenicline, nicotine, cotinine, 3'-hydroxycotinine, and 3'-hydroxycotinine/cotinine (3HC/COT) ratio in quality control saliva samples (and after repeated freezing and thawing), and in smokers' saliva samples, stored for up to 21 days at room temperature (~25°C), 4°C, and -80°C.

Results

In saliva quality control samples, conce

SUBMITTER: Novalen M 

PROVIDER: S-EPMC9013001 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature