Development of a portable hypoxia chamber for ultra-high dose rate laser-driven proton radiobiology applications.

ABSTRACT:

Background

There is currently significant interest in assessing the role of oxygen in the radiobiological effects at ultra-high dose rates. Oxygen modulation is postulated to play a role in the enhanced sparing effect observed in FLASH radiotherapy, where particles are delivered at 40-1000 Gy/s. Furthermore, the development of laser-driven accelerators now enables radiobiology experiments in extreme regimes where dose rates can exceed 10⁹ Gy/s, and predicted oxygen depletion effects on cellular response can be tested. Access to appropriate experimental enviroments, allowing measurements under controlled oxygenation conditions, is a key requirement for these studies. We report on the development and application of a bespoke portable hypoxia chamber specifically designed f

SUBMITTER: Chaudhary P 

PROVIDER: S-EPMC9013042 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature