Prognostic value of left atrial mechanics in cardiac light-chain amyloidosis with preserved ejection fraction: a cohort study.

ABSTRACT:

Background

Light-chain amyloidosis is a plasma cell disorder associated with poor outcomes, especially when the heart is involved. The characteristics of left atrial (LA) function and its prognostic implications in cardiac amyloidosis (CA) have not been fully investigated.

Methods

Between April 2014 and June 2019, 93 patients with a diagnosis of CA, normal left ventricular ejection fraction (LVEF) and sinus rhythm were included. Their clinical, baseline echocardiographic and follow-up data were investigated. LA function, including LA strain and strain rate, was assessed using 2D speckle tracking echocardiography in different LA functional phases.

Results

Among all patients, 38 (40.9%) died. Multivariate Cox regression analyses showed that LA mechanics regarding LA res

SUBMITTER: Liu XH 

PROVIDER: S-EPMC9013068 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature