Prenatal sonographic findings in confirmed cases of Wolf-Hirschhorn syndrome.

ABSTRACT:

Background

Wolf-Hirschhorn syndrome (WHS) is a common genetic condition and prenatal diagnosis is difficult due to heterogeneous expression of this syndrome and rather non-specific ultrasound findings. Objective of this study was to examine the prenatal ultrasound findings in fetuses with Wolf-Hirschhorn syndrome (WHS).

Methods

Retrospective assessment of 18 pregnancies that were seen at three tertiary referral centers (Universities of Bonn, Tuebingen and Nuernberg / Germany). Findings of prenatal ultrasound examinations, genetic results and outcome were compared. Additionally, findings of our study were compared to previous small case series from the literature and then compared to data on postnatal frequencies and abnormalities in affected patients.

Results

Median g

SUBMITTER: Simonini C 

PROVIDER: S-EPMC9013087 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature