Role of integrins in the metastatic spread of high-grade serous ovarian cancer.

ABSTRACT:

Purpose

Integrins may be involved in the metastatic spread of high-grade serous ovarian cancer (HGSOC) which determines the therapeutical approach and prognosis. We investigated the integrin expression in primary tumor and metastases of advanced HGSOC.

Methods

The expression of integrin α2, α4, α5, α6, and β1 was assessed by immunostaining in tumor samples of the ovary, omentum, and peritoneum of each patient. Differences in integrin expression among tumor localizations and their association with clinicopathological parameters were examined by Fisher's exact test. The impact of integrin expression on progression-free survival (PFS) and overall survival (OS) was examined by Cox regression and Kaplan-Meier analyses.

Results

Hundred and thirteen tumor samples of 40 HGSOC

SUBMITTER: Krajnak S 

PROVIDER: S-EPMC9013321 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature