The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone.

ABSTRACT: Adult neurogenesis has been described in two canonical regions of the adult central nervous system (CNS) of rodents, the subgranular zone (SGZ) of the hippocampus and the subependymal zone (SEZ) of the lateral ventricles. The stem cell niche of the SEZ provides a privileged environment composed of a specialized extracellular matrix (ECM) that comprises the glycoproteins tenascin-C (Tnc) and laminin-1 (LN1). In the present study, we investigated the function of these ECM glycoproteins in the adult stem cell niche. Adult neural stem/progenitor cells (aNSPCs) of the SEZ were prepared from wild type (Tnc^+/+) and Tnc knockout (Tnc^-/-) mice and analyzed using molecular and cell biological approaches. A delayed maturation of aNSPCs in Tnc^-/- tissue was reflected b

SUBMITTER: Schaberg E 

PROVIDER: S-EPMC9013340 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature