Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects.

ABSTRACT: Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenua

SUBMITTER: Pollok TM 

PROVIDER: S-EPMC9013474 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature