Structure and the Mode of Activity of Lon Proteases from Diverse Organisms.

ABSTRACT: Lon proteases, members of the AAA⁺ superfamily of enzymes, are key components of the protein quality control system in bacterial cells, as well as in the mitochondria and other specialized organelles of higher organisms. These enzymes have been subject of extensive biochemical and structural investigations, resulting in 72 crystal and solution structures, including structures of the individual domains, multi-domain constructs, and full-length proteins. However, interpretation of the latter structures still leaves some questions unanswered. Based on their amino acid sequence and details of their structure, Lon proteases can be divided into at least three subfamilies, designated as LonA, LonB, and LonC. Protomers of all Lons are single-chain polypeptides and contain two functional

SUBMITTER: Wlodawer A 

PROVIDER: S-EPMC9013511 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature