Mechanism of Jujube (Ziziphus jujuba Mill.) Fruit in the Appetite Regulation Based on Network Pharmacology and Molecular Docking Method.

ABSTRACT:

Objective

To investigate the mechanism of jujube (Ziziphus jujuba Mill.) in appetite regulation based on network pharmacology.

Methods

The active components and action targets of jujube were retrieved through the TCMSP and TCMID databases. GeneCards, DisGeNet, Therapeutic Target Database, and OMIM were used to screen the related targets for appetite, appetite suppression, and appetite regulation, and the intersection target of the two was selected. A protein-protein interaction (PPI) network was constructed. Important protein nodes and subnets were predicted based on the cytoHubba plug-in, and the hub gene was screened. Additionally, GO and KEGG pathway analyses were performed to obtain potential biological processes and signaling pathways of key targets. And the acti

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9013574 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature