Identification of a DNA damage repair gene-related signature for lung squamous cell carcinoma prognosis.

ABSTRACT:

Background

DNA damage repair (DDR) plays a role in the tumorigenesis and progression of lung squamous cell carcinoma (LUSC), but the predictive value of DDR in LUSC has not been fully elucidated.

Methods

The LUSC datasets were retrieved from the Cancer Genome Atlas databases. Univariate Cox regression and least absolute shrinkage and selection operator regression were integrated to identify critical genes and construct a DDR gene signature. We performed Kaplan-Meier (KM) curve to compare the overall survival (OS) between the two groups based on DDR signature and used the CIBERSORT tool to compare the immune cell composition. Further gene set enrichment analysis (GSEA) was performed on the differential expressed genes.

Result

We established the DDR-related gene signatu

SUBMITTER: Jia B 

PROVIDER: S-EPMC9013644 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature