Hyperdynamic left ventricular ejection fraction is associated with higher mortality in COVID-19 patients.

ABSTRACT:

Study objective

To compare the characteristics and outcomes of COVID-19 patients with a hyperdynamic LVEF (HDLVEF) to those with a normal or reduced LVEF.

Design

Retrospective study.

Setting

Rush University Medical Center.

Participants

Of the 1682 adult patients hospitalized with COVID-19, 419 had a transthoracic echocardiogram (TTE) during admission and met study inclusion criteria.

Interventions

Participants were divided into reduced (LVEF < 50%), normal (≥50% and <70%), and hyperdynamic (≥70%) LVEF groups.

Main outcome measures

LVEF was assessed as a predictor of 60-day mortality. Logistic regression was used to adjust for age and BMI.

Results

There was no difference in 60-day mortality between patients in the reduced LVEF and normal LVEF groups (adjusted odds ratio [aOR] 0.87, p = 0.68). However, patients with an HDLVEF were more likely to die by 60 days compared to patients in the normal LVEF group (aOR 2.63 [CI: 1.36-5.05]; p < 0.01). The HDLVEF group was also at higher risk for 60-day mortality than the reduced LVEF group (aOR 3.34 [CI: 1.39-8.42]; p < 0.01).

Conclusion

The presence of hyperdynamic LVEF during a COVID-19 hospitalization was associated with an increased risk of 60-day mortality, the requirement for mechanical ventilation, vasopressors, and intensive care unit.

SUBMITTER: Rahman A 

PROVIDER: S-EPMC9013697 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature