Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity.

ABSTRACT:

Background

Cannabinoids modulate the activation of immune cells and physiologic processes in the lungs. Group 2 innate lymphoid cells (ILC2s) are central players in type 2 asthma, but how cannabinoids modulate ILC2 activation remains to be elucidated.

Objective

Our goal was to investigate the effects of cannabinoids on ILC2s and their role in asthma.

Methods

A combination of cannabinoid receptor (CB)₂ knockout (KO) mice, CB₂ antagonist and agonist were used in the mouse models of IL-33, IL-25, and Alternaria alternata ILC2-dependent airway inflammation. RNA sequencing was performed to assess transcriptomic changes in ILC2s, and humanized mice were used to assess the role of CB₂ signaling in human ILC2s.

Results

We provide eviden

SUBMITTER: Hurrell BP 

PROVIDER: S-EPMC9013728 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature