Dynamic and Static Amplitude of Low-Frequency Fluctuation Is a Potential Biomarker for Predicting Prognosis of Degenerative Cervical Myelopathy Patients: A Preliminary Resting-State fMRI Study.

ABSTRACT:

Objective

The aim of this study was to explore the clinical value of the static amplitude of low-frequency fluctuation (sALFF) and dynamic amplitude of low-frequency fluctuation (dALFF) in the identification of brain functional alterations in degenerative cervical myelopathy (DCM) patients.

Methods

Voxel-wise sALFF and dALFF of 47 DCM patients and 44 healthy controls were calculated using resting-state fMRI data, and an intergroup comparison was performed. The mean of sALFF or dALFF data were extracted within the resultant clusters and the correlation analysis of these data with the clinical measures was performed. Furthermore, whole-brain-wise and region-wise multivariate pattern analyses (MVPAs) were performed to classify DCM patients and healthy controls. sALFF and dALFF

SUBMITTER: Fan N 

PROVIDER: S-EPMC9013796 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature