Increased Expression of Syncytin-1 in Skeletal Muscle of Humans With Increased Body Mass Index.

ABSTRACT: Obesity negatively impacts skeletal muscle protein metabolism, and also impairs skeletal muscle maintenance and regeneration. We analyzed muscle biopsy samples from humans with increased body mass index (BMI) (i.e. > 30 kg/m²) and controls (i.e., BMI < 25 kg/m²) for expression of syncytin-1, a fusogenic protein regulating skeletal muscle regeneration. When compared to controls, humans with increased BMI and concomitant reduction in muscle protein synthesis had higher expression of syncytin-1 in skeletal muscle (p < 0.05). Across human subjects, muscle protein synthesis correlated inversely (r = -0.51; p = 0.03) with syncytin-1 expression in muscle. Using a C2C12 cell line we found that expression of syncytin-A (i.e, corresponding protein in murine

SUBMITTER: Ravichandran J 

PROVIDER: S-EPMC9013906 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature