Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7.
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ABSTRACT:
SUBMITTER: Weaver GC
PROVIDER: S-EPMC9013968 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
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Structural Models for Roseolovirus U20 And U21: Non-Classical MHC-I Like Proteins From HHV-6A, HHV-6B, and HHV-7.
Weaver Grant C GC Arya Richa R Schneider Christine L CL Hudson Amy W AW Stern Lawrence J LJ
Frontiers in immunology 20220404
Human roseolovirus U20 and U21 are type I membrane glycoproteins that have been implicated in immune evasion by interfering with recognition of classical and non-classical MHC proteins. U20 and U21 are predicted to be type I glycoproteins with extracytosolic immunoglobulin-like domains, but detailed structural information is lacking. AlphaFold and RoseTTAfold are next generation machine-learning-based prediction engines that recently have revolutionized the field of computational three-dimension ...[more]
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