Antiretroviral therapy uptake and predictors of virological failure in patients with HIV receiving first-line and second-line regimens in Johannesburg, South Africa: a retrospective cohort data analysis.

ABSTRACT:

Objective

This study described the demographics, treatment information and identified characteristics associated with virological failure and being lost to follow-up (LTFU) for patients with HIV on first-line and second-line antiretroviral therapy (ART) regimens in a large South African cohort.

Design

A quantitative retrospective cohort study using secondary data analysis.

Setting

Seven Johannesburg inner city facilities.

Participants

Unique records of 123 002 people with HIV receiving ART at any point in the period 1 April 2004 to 29 February 2020 were included.

Measures

Demographic characteristics, ART status, CD4 count information and retention status were collected and analysed as covariates of outcomes (viral load (VL) and LTFU).

Results

Of t

SUBMITTER: Gumede SB 

PROVIDER: S-EPMC9013990 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature