Immune correlates of clinical parameters in patients with HPV-associated malignancies treated with bintrafusp alfa.

ABSTRACT:

Purpose

Bintrafusp alfa is a bifunctional agent consisting of an anti-human PD-L1 antibody linked to two TGFβRII. It is designed to act both as a checkpoint inhibitor and to 'trap' TGFβ in the tumor microenvironment. Phase I and II clinical studies demonstrated clinical activity in patients with a range of human papillomavirus (HPV)-associated cancers. The purpose of the studies reported here was the interrogation of various aspects of the peripheral immunome in patients with HPV-associated cancers, both prior to and early in the treatment regimen of bintrafusp alfa to better understand the mode of action of the agent and to help define which patients are more likely to benefit from bintrafusp alfa treatment.

Patients and methods

The peripheral immunome of patients (n=65) wi

SUBMITTER: Tsai YT 

PROVIDER: S-EPMC9014099 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature