A cohort study of duplicate faecal immunochemical testing in patients at risk of colorectal cancer from North-West England.

ABSTRACT:

Objectives

We sought to investigate if duplicate faecal immunochemical testing (FIT) sampling improves the negative and positive predictive value of patients thought to be at risk of colorectal cancer (CRC). Specifically, we aimed to investigate whether the proportion of FIT-negative CRC missed by a single FIT test in symptomatic patients could be reduced by duplicate FIT testing.

Design

A retrospective service evaluation cohort study of the diagnostic accuracy of duplicate FIT testing.

Setting

Patients referred from primary care with suspected CRC to four secondary care trusts in North-West England.

Participants

28 622 patients over 18-years-old with lower gastrointestinal symptoms suggestive of CRC who completed two FIT samples.

Primary and secondary outco

SUBMITTER: Hunt N 

PROVIDER: S-EPMC9014104 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature