Cortical Thickness Changes After Computerized Working Memory Training in Patients With Mild Cognitive Impairment.

ABSTRACT:

Background

Adaptive computerized working memory (WM) training has shown favorable effects on cerebral cortical thickness as compared to non-adaptive training in healthy individuals. However, knowledge of WM training-related morphological changes in mild cognitive impairment (MCI) is limited.

Objective

The primary objective of this double-blind randomized study was to investigate differences in longitudinal cortical thickness trajectories after adaptive and non-adaptive WM training in patients with MCI. We also investigated the genotype effects on cortical thickness trajectories after WM training combining these two training groups using longitudinal structural magnetic resonance imaging (MRI) analysis in Freesurfer.

Method

Magnetic resonance imaging acquisition at 1.5

SUBMITTER: Hol HR 

PROVIDER: S-EPMC9014119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature