A low-cost pathological image digitalization method based on 5 times magnification scanning.

ABSTRACT:

Background

Digital pathology has aroused widespread interest in modern pathology. The key to digitalization is to scan the whole slide image (WSI) at high magnification. The file size of each WSI at 40 times magnification (40×) may range from 1 gigabyte (GB) to 5 GB depending on the size of the specimen, which leads to huge storage capacity, very slow scanning and network exchange, seriously increasing time and storage costs for digital pathology.

Methods

We design a strategy to scan slides with low resolution (LR) (5×), and a superresolution (SR) method is proposed to restore the image details during diagnosis. The method is based on a multiscale generative adversarial network, which can sequentially generate three high-resolution (HR) images: 10×, 20×, and 40×. A dataset c

SUBMITTER: Sun K 

PROVIDER: S-EPMC9014144 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature