Normalisation of airflow limitation in asthma: Post-hoc analyses of TRIMARAN and TRIGGER.

ABSTRACT:

Background

In asthma, persistent airflow limitation (PAL) is associated with poorer control, lung function decline and exacerbations. Using post-hoc analyses we evaluated: the relationship between post-salbutamol PAL at screening, airflow limitation (AL) during 52 weeks treatment with extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) versus BDP/FF and the risk of moderate/severe asthma exacerbations.

Methods

TRIMARAN and TRIGGER were double-blind studies comparing BDP/FF/G with BDP/FF (TRIMARAN medium-dose ICS; TRIGGER high-dose) in adults with uncontrolled asthma. Patients were subgrouped according to post-salbutamol PAL status at screening, and AL over the 52-week treatment period.

Results

Most patients with post-salbutamol PAL at sc

SUBMITTER: Papi A 

PROVIDER: S-EPMC9014197 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature