Higher Dementia Risk in People With Gastroesophageal Reflux Disease: A Real-World Evidence.

ABSTRACT:

Background

Whether or not patients with gastroesophageal reflux disease (GERD) have a higher risk of developing subsequent dementia remains unknown, and no observational evidence from population-based data is available. This study was to determine whether patients with GERD have a higher future risk of developing dementia.

Methods

For the period 2000-2012, datasets from the Longitudinal Health Insurance Database (LHID, subset of National Health Insurance Research Database in Taiwan) were analyzed. Definition of GERD was based on ICD-9-CM codes 530.11 and 530.81 and prescriptions for PPIs. After matching gender, age, index year, and comorbidities, each GERD patient was matched with four control patients without GERD. Future risk of dementia was evaluated, and sensitivity anal

SUBMITTER: Gau SY 

PROVIDER: S-EPMC9014245 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature