Decoupling the role of chemistry and microstructure in hMSCs response to an osteoinductive calcium phosphate ceramic.

ABSTRACT: Calcium phosphates (CaP) are widely used synthetic bone graft substitutes, having bioactivity that is regulated by a set of intertwined physico-chemical and structural properties. While some CaPs have shown to be as effective in regenerating large bone defects as autologous bone, there is still the need to understand the role of individual material properties in CaP performance. Here, we aimed to decouple the effects of chemical composition and surface-microstructure of a beta-tricalcium phosphate (TCP) ceramic, with proven osteoinductive potential, on human mesenchymal stromal cells (hMSCs) differentiation. To this end, we replicated the surface structure of the TCP ceramic into polylactic acid without inorganic additives, or containing the chemical constituents of the ceramic, i.e., a ca

SUBMITTER: Galvan-Chacon VP 

PROVIDER: S-EPMC9014318 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature