Design of an Epitope-Based Peptide Vaccine Against Dengue Virus Isolate from Eastern Uttar Pradesh, India.

ABSTRACT: Dengue outbreaks are a serious public health concern that occurs on a regular basis in various locations of India. According to the Government of India's National Center for Vector-Borne Disease Control, a total of 1,23,106 dengue cases were identified in India as of October 2021. The currently available dengue vaccine was found to be ineffective against all serotypes of the virus. Dengue virus serotype 2 was reported to be the sole predominant serotype in Eastern Uttar Pradesh, India. An epitope-based peptide vaccine is believed to be safe and effective against all serotypes of the dengue virus. In this work, an epitope-based peptide vaccine based on envelope protein against the dengue virus was developed using the reverse vaccinology method. T-cell epitopes present in the envelope protei

SUBMITTER: Gupta S 

PROVIDER: S-EPMC9014403 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature