Ontology highlight
ABSTRACT:
SUBMITTER: Decara JM
PROVIDER: S-EPMC9014410 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Decara Juan M JM Vázquez-Villa Henar H Brea José J Alonso Mónica M Srivastava Raj Kamal RK Orio Laura L Alén Francisco F Suárez Juan J Baixeras Elena E García-Cárceles Javier J Escobar-Peña Andrea A Lutz Beat B Rodríguez Ramón R Codesido Eva E Garcia-Ladona F Javier FJ Bennett Teresa A TA Ballesteros Juan A JA Cruces Jacobo J Loza María I MI Benhamú Bellinda B Rodríguez de Fonseca Fernando F López-Rodríguez María L ML
Journal of medicinal chemistry 20220329 7
Peptidic agonists of the glucagon-like peptide-1 receptor (GLP-1R) have gained a prominent role in the therapy of type-2 diabetes and are being considered for reducing food intake in obesity. Potential advantages of small molecules acting as positive allosteric modulators (PAMs) of GLP-1R, including oral administration and reduced unwanted effects, could improve the utility of this class of drugs. Here, we describe the discovery of compound <b>9</b> (4-{[1-({3-[4-(trifluoromethyl)phenyl]-1,2,4-o ...[more]