A fully resolved multiphysics model of gastric peristalsis and bolus emptying in the upper gastrointestinal tract.

ABSTRACT: Over the past few decades, in silico modeling of organ systems has significantly furthered our understanding of their physiology and biomechanical function. In spite of the relative importance of the digestive system in normal functioning of the human body, there is a scarcity of high-fidelity models for the upper gastrointestinal tract including the esophagus and the stomach. In this work, we present a detailed numerical model of the upper gastrointestinal tract that not only accounts for the fiber architecture of the muscle walls, but also the multiphasic components they help transport during normal digestive function. Construction details for 3D models of representative stomach geometry are presented along with a simple strategy for assigning circular and longitudinal muscle fiber orien

SUBMITTER: Acharya S 

PROVIDER: S-EPMC9014465 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature