Central stress processing, T-cell responsivity to stress hormones and disease severity in multiple sclerosis.

ABSTRACT: Epidemiological, clinical and neuroscientific studies support a link between psychobiological stress and multiple sclerosis. Neuroimaging suggests that blunted central stress processing goes along with higher multiple sclerosis severity, neuroendocrine studies suggest that blunted immune system sensitivity to stress hormones is linked to stronger neuroinflammation. Until now, however, no effort has been made to elucidate whether central stress processing and immune system sensitivity to stress hormones are related in a disease-specific fashion, and if so, whether this relation is clinically meaningful. Consequently, we conducted two functional MRI analyses based on a total of 39 persons with multiple sclerosis and 25 healthy persons. Motivated by findings of an altered interplay between ne

SUBMITTER: Brasanac J 

PROVIDER: S-EPMC9014535 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature