Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

ABSTRACT: The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood^1-3. Here, to identify a phenotypically robust core set of genes and pathways that enable cancer cells to evade killing mediated by cytotoxic T lymphocytes (CTLs), we performed genome-wide CRISPR screens across a panel of genetically diverse mouse cancer cell lines that were cultured in the presence of CTLs. We identify a core set of 182 genes across these mouse cancer models, the individual perturbation of which increases either the sensitivity or the resistance of cancer cells to CTL-mediated toxicity. Systematic exploration of our dataset using genetic co-similarity reveals the hierarchical and coordinated manner in which genes and pathways act in cancer cells t

SUBMITTER: Lawson KA 

PROVIDER: S-EPMC9014559 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature