Planning a method for covariate adjustment in individually randomised trials: a practical guide.

ABSTRACT:

Background

It has long been advised to account for baseline covariates in the analysis of confirmatory randomised trials, with the main statistical justifications being that this increases power and, when a randomisation scheme balanced covariates, permits a valid estimate of experimental error. There are various methods available to account for covariates but it is not clear how to choose among them.

Methods

Taking the perspective of writing a statistical analysis plan, we consider how to choose between the three most promising broad approaches: direct adjustment, standardisation and inverse-probability-of-treatment weighting.

Results

The three approaches are similar in being asymptotically efficient, in losing efficiency with mis-specified covariate functions and in

SUBMITTER: Morris TP 

PROVIDER: S-EPMC9014627 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature