Sunitinib-related high-grade proteinuria and allograft dysfunction in a kidney recipient: a rare case report.

ABSTRACT:

Background

Sunitinib-induced high-grade proteinuria and irreversible renal allograft dysfunction are rare conditions. Here, we present a patient who had received renal allograft and later developed metastatic clear cell renal cell carcinoma(cc-mRCC), for which he was prescribed sunitinib. High-grade proteinuria, hypoalbuminemia, peripheral edema and renal allograft dysfunction (manifesting as an increase in the serum creatinine concentration) occurred 5 months after sunitinib prescription.

Case presentation

The patient was a 58-year-old male who had end-stage renal disease with regular hemodialysis through arteriovenous fistula for 17 years since 1998 and received a renal allograft from a deceased kidney donor in 2015. Unfortunately, in 2019, the patient developed cc-mRCC or

SUBMITTER: Ko HC 

PROVIDER: S-EPMC9014636 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature