Challenges of modelling approaches for network meta-analysis of time-to-event outcomes in the presence of non-proportional hazards to aid decision making: Application to a melanoma network.

ABSTRACT:

Background

Synthesis of clinical effectiveness from multiple trials is a well-established component of decision-making. Time-to-event outcomes are often synthesised using the Cox proportional hazards model assuming a constant hazard ratio over time. However, with an increasing proportion of trials reporting treatment effects where hazard ratios vary over time and with differing lengths of follow-up across trials, alternative synthesis methods are needed.

Objectives

To compare and contrast five modelling approaches for synthesis of time-to-event outcomes and provide guidance on key considerations for choosing between the modelling approaches.

Methods

The Cox proportional hazards model and five other methods of estimating treatment effects from time-to-event outcomes, w

SUBMITTER: Freeman SC 

PROVIDER: S-EPMC9014691 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature