High Expression of CSF-1R Predicts Poor Prognosis and CSF-1R^high Tumor-Associated Macrophages Inhibit Anti-Tumor Immunity in Colon Adenocarcinoma.

ABSTRACT:

Background

Colony stimulating factor 1 receptor (CSF-1R) is a single channel III transmembrane receptor tyrosine kinase (RTK) and plays an important role in immune regulation and the development of various cancer types. The expression of CSF-1R in colon adenocarcinoma (COAD) and its prognostic value remain incompletely understood. Therefore, we aim to explore the prognostic value of CSF-1R in COAD and its relationship with tumor immunity.

Methods

CSF-1R expression in a COAD cohort containing 103 patients was examined using immunohistochemistry (IHC). The relationship between CSF-1R expression and clinicopathological parameters and prognosis was evaluated. Dual immunofluorescence staining was conducted to determine the localization of CSF-1R in COAD tissues. Univariate and mu

SUBMITTER: Wang X 

PROVIDER: S-EPMC9014714 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature