Personalized dosimetry of¹⁷⁷Lu-DOTATATE: a comparison of organ- and voxel-level approaches using open-access images.

ABSTRACT: ¹⁷⁷Lu-DOTATATE (Lutathera^®) enables targeted radionuclide therapy of neuroendocrine tumors expressing somatostatin receptor type 2. Though patient-specific dosimetry estimates may be clinically important for predicting absorbed dose-effect relationships, there are multiple relevant dosimetry paradigms which are distinct in terms of clinical effort, numerical output and added-value. This work compares three different approaches for¹⁷⁷Lu-DOTATATE dosimetry, including 1) an organ-level approach based on reference phantom MIRD S-values scaled to patient-specific organ masses (MIRDcalc), 2) an organ-level approach based on Monte Carlo simulation in a patient-specific mesh phantoms (PARaDIM), and 3) a 3D approach based on Monte Carlo simulation in patient-specifi

SUBMITTER: Carter LM 

PROVIDER: S-EPMC9014836 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature