Cigarette smoke-induced extracellular vesicles from dendritic cells alter T-cell activation and HIV replication.

ABSTRACT: Despite decreased rates of tobacco smoking in many areas, cigarette smoking remains a major contributor to many health problems. Cigarette smoking can reduce immune system functioning while concurrently increasing inflammation. Dendritic cells in the lung exposed to cigarette smoke become stimulated and go on to activate T-cells. Extracellular vesicles (EVs) are nano-sized particles released by cells. They participate in intercellular communication by transferring functional proteins and nucleic acids to recipient cells and have been implicated in immune responses. For example, they can display MHC-peptide complexes to activate T-cells. In the current study, we sought to understand the role of cigarette smoke extract (CSE) on dendritic cell-derived EVs and their capacity to activate and di

SUBMITTER: Russell AE 

PROVIDER: S-EPMC9014967 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature